WebSolifenacin succinate, like other anticholinergics should be used with caution in patients with decreased gastrointestinal motility. Hepatic Solifenacin succinate should be used with caution in patients with reduced hepatic function. Doses of Solifenacin succinate greater than 5 mg are not recommended in patients with moderate hepatic impairment. Solifenacin, sold as the brand name Vesicare among others, is a medicine used to treat overactive bladder and neurogenic detrusor overactivity (NDO). It may help with incontinence, urinary frequency, and urinary urgency. Benefits appear similar to other medications in the class. It is taken by mouth. Common side … See more It is used to treat overactive bladder. It may help with incontinence, urinary frequency, and urinary urgency. Benefits appear similar to other antimuscarinics such as oxybutynin, tolterodine, … See more The most common side effects of solifenacin are dry mouth, constipation and urinary tract infection. As all anticholinergics, … See more Mechanism of action Solifenacin is a competitive cholinergic receptor antagonist, selective for the M3 receptor subtype. The binding of acetylcholine to these receptors, particularly M3, plays a critical role in the contraction of See more The compound was studied using animal models by the Yamanouchi Pharmaceutical Co., Ltd. of Tokyo, Japan. It was known as YM905 when under study in the early 2000s. See more Solifenacin is contraindicated for people with urinary retention, gastric retention, uncontrolled or poorly controlled closed-angle glaucoma, severe liver disease (Child-Pugh class … See more Solifenacin is metabolized in the liver by the cytochrome P450 enzyme CYP3A4. When administered concomitantly with drugs that See more Like other anticholinergics, solifenacin is an ester of a carboxylic acid containing (at least) an aromatic ring with an alcohol containing a … See more
Solifenacin (Oral Route) Description and Brand Names - Mayo Clinic
WebDec 15, 2024 · Solifenacin succinate is a white to pale-yellowish-white crystal or crystalline powder. It is freely soluble at room temperature in water, glacial acetic acid, dimethyl sulfoxide, and methanol. Each Solifenacin Succinate tablet contains 5 or 10 mg of solifenacin succinate and is for oral administration. WebThis video shows you how to pronounce Solifenacin raymond orthober
(PDF) Pharmaceutical Analysis of Different Brands of Solifenacin ...
WebP/0260/2014: EMA decision of 29 September 2014 on the acceptance of a modification of an agreed paediatric investigation plan for solifenacin (succinate) (Vesicare and … WebSolifenacin succinate is the international common denomination for butanedioic acid compounded with (1S)- (3R)-1-azabicyclo [2.2.2]oct-3-yl-3,4-dihydro-1-phenyl-2 (1H)— isoquinolinecarboxylate (1:1), having an empirical formula of C 23 H 26 N 2 O 2 .C 4 H 6 O 4 and the structure represented in formula I given below. WebJul 20, 2024 · Solifenacin 5 mg is a white to yellowish rounded biconvex film-coated tablet with a diameter of 8.0-8.2 mm. Solifenacin 10 mg is a pink rounded biconvex film-coated … raymond ortlund