Non-cell-autonomous OTX2 transcription factor regulates …

WebDec 26, 2024 · Conclusions . While OTX2 mutations are known to cause retinopathy, this case presents a unique phenotype through a heterozygous missense variant (c.235 G > A) underlying high myopia in a three-generation family. This case further supports the role of OTX2 in ocular development and demonstrates the variable expressivity of OTX2 … WebOtx2, which is an encoded protein that plays the role of a transcription factor, has also been shown to be involved in the regional patterning of the midbrain and forebrain. This group … kings drug chipley fl

WebDeletion of Otx2 in vivo increases PGC numbers. These data demonstrate that OTX2 functions repressively upstream of PGC transcription factors, acting as a roadblock to limit entry of epiblast cells to the germline to a small window in space and time, thereby ensuring correct numerical segregation of germline cells from the soma. WebDec 13, 2024 · Jellyfish come in a wide variety of shapes and sizes. The largest is the lion's mane jellyfish (Cyanea capillata), which can have a bell over six and a half feet in diameter and weigh up to 440 pounds; the smallest is the Irukandji jellyfish, several species of dangerous jellyfishes found in tropical waters, which measure only about two-tenths of an … kings drugs chipley fl