WebThere is evidence to suggest that transcription factor KLF4 plays a crucial role in the progression of breast carcinoma, 14 squamous cell carcinoma, 15 lung cancer, 16 and … WebAug 28, 2013 · General functions of KLF4 3.1. Inhibition of cell proliferation KLF4 is known to induce growth arrest, inhibiting cell proliferation by regulating the expression of key cell …
Function of KLF4 in Stem Cell Biology IntechOpen
WebFeb 25, 2013 · Thereby, Klf4 acts as a transcriptional activator of epithelial genes and as a repressor of mesenchymal genes. Specifically, increased expression of Jnk1 (Mapk8) … WebApr 8, 2024 · The exact molecular mechanisms how KLF4 executes its function in tumors remains unclear, although the most important molecules downstream KLF4 include P21, P27, P53 and Cyclin-D. Whether KLF4 ... mycustompuppet
Kruppel-like Factor 4 (Klf4) Prevents Embryonic Stem (ES) Cell ...
WebMar 21, 2024 · KLF4 (KLF Transcription Factor 4) is a Protein Coding gene. Diseases associated with KLF4 include Epilepsy, Idiopathic Generalized 15 and Familial Adenomatous Polyposis . Among its related pathways are … WebFurthermore, KLF4 was shown to activate the p38 MAPK signaling pathway to promote cancer stemness. Altogether, our studies uncover an essential role for KLF4 in regulation … WebDec 3, 2024 · Both KLF4 and Sp5 have been shown to regulate naive pluripotency in part through the transcriptional regulation of Nanog, whose downregulation marks the exit of ESCs from the naive state into a state that is primed for lineage specification 29 – 31. Interestingly, we observed downregulation of both Nanog and Klf4 in I-BRD9-treated ESCs … office of the inspector general doj