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Klf4 function

WebThere is evidence to suggest that transcription factor KLF4 plays a crucial role in the progression of breast carcinoma, 14 squamous cell carcinoma, 15 lung cancer, 16 and … WebAug 28, 2013 · General functions of KLF4 3.1. Inhibition of cell proliferation KLF4 is known to induce growth arrest, inhibiting cell proliferation by regulating the expression of key cell …

Function of KLF4 in Stem Cell Biology IntechOpen

WebFeb 25, 2013 · Thereby, Klf4 acts as a transcriptional activator of epithelial genes and as a repressor of mesenchymal genes. Specifically, increased expression of Jnk1 (Mapk8) … WebApr 8, 2024 · The exact molecular mechanisms how KLF4 executes its function in tumors remains unclear, although the most important molecules downstream KLF4 include P21, P27, P53 and Cyclin-D. Whether KLF4 ... mycustompuppet https://liverhappylife.com

Kruppel-like Factor 4 (Klf4) Prevents Embryonic Stem (ES) Cell ...

WebMar 21, 2024 · KLF4 (KLF Transcription Factor 4) is a Protein Coding gene. Diseases associated with KLF4 include Epilepsy, Idiopathic Generalized 15 and Familial Adenomatous Polyposis . Among its related pathways are … WebFurthermore, KLF4 was shown to activate the p38 MAPK signaling pathway to promote cancer stemness. Altogether, our studies uncover an essential role for KLF4 in regulation … WebDec 3, 2024 · Both KLF4 and Sp5 have been shown to regulate naive pluripotency in part through the transcriptional regulation of Nanog, whose downregulation marks the exit of ESCs from the naive state into a state that is primed for lineage specification 29 – 31. Interestingly, we observed downregulation of both Nanog and Klf4 in I-BRD9-treated ESCs … office of the inspector general doj

Klf4 Kruppel-like factor 4 (gut) [ (house mouse)] - National Center …

Category:Krüppel-Like Factor-4 Transcriptionally Regulates VE-Cadherin ...

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Klf4 function

The transcription factor KLF4 as an independent predictive marker …

WebBackground & aims: Krüppel-like factor 4 (KLF4) is a transcription factor associated with tumor suppression and oncogenesis. KLF4 suppresses pancreatic tumorigenesis by unknown mechanisms; we investigated alterations that might affect KLF4 function and lead to tumor formation. WebNov 25, 2024 · Here, we report that Krüppel-like factor 4 (KLF4) is a critical regulator of the exhaustion process, promoting the cytolytic effector function of exhausted CD8 T cells. …

Klf4 function

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WebMar 19, 2010 · Transcription factor Kruppel-like factor 4 (Klf4) is essential for somatic cell reprogramming. In addition, Klf4 seems to play a redundant role along with other Klf family proteins in embryonic stem (ES) cell self-renewal. However, how Klf4 regulates ES cell self-renewal and somatic cell reprogramming is still poorly understood. Here we report that … WebSep 23, 2024 · The architectural function of KLF4 is further supported by the observations that KLF4 depletion abrogates long-range chromatin contacts at specific genomic loci, …

WebJun 28, 2013 · The Krüppel-like factor 4 is a DNA-binding transcriptional regulator that regulates a diverse array of cellular processes, including development, differentiation, … WebFeb 19, 2024 · KLF4 is a therapeutically tractable brake on fibroblast activation that promotes resolution of pulmonary fibrosis. Penke LR, et al. JCI Insight, 2024 Aug 22. PMID 35852857, Free PMC Article. Decreased Krüppel-like factor 4 in adenomyosis impairs decidualization by repressing autophagy in human endometrial stromal cells.

WebKlf4 inhibits proliferation through activation of p21Cip1/Waf1, and direct suppression of cyclin D1 and cyclin B1 gene expression. Both Klf4 & Klf5 proteins act on the Klf4 … WebDec 10, 2024 · KLF4 expression is upregulated in PDGFR-β + cells and their lineage during disease pathogenesis. Reduction of KLF4 in PDGFR-β + cells attenuates fibrosis, at least in part by downregulating...

WebApr 12, 2024 · KLF4 is required for normal smooth muscle cell function and coverage of resistance arteries. Transgenic mice with overexpression of KLF4 were subjected to …

WebKLF4 belongs to the Kruppel-like factor (KLF) family, a group of conserved zinc finger TFs that regulates essential biological processes such as proliferation and development. … my custom print shopWebSep 30, 2015 · KLF4 is an important regulator of cell-fate decision, including DNA damage response and apoptosis. We identify a novel interplay between protein modifications in regulating KLF4 function. office of the inspector general hudWebNov 25, 2010 · KLF4 (gut Krüppel-like factor) was initially identified in the epithelial lining of the gut and skin. 39 Indeed, KLF4 knockout mice exhibit abnormal epidermal differentiation and, as a consequence, die within hours after birth 40 ; in addition, KLF4 has been found to be essential for colonic goblet cell differentiation. 41 KLF4 has also been … office of the inspector general california