WebJan 1, 2014 · The potential candidates of cochlear stem cells are the supporting cells, the cells at lesser epithelial ridge (LER), the cells at greater epithelial ridge (GER), and the tympanic border cells. The number of stem cells in the inner ear is estimated to be very low and is reported to decrease dramatically with maturation. It is necessary to ... WebThe greater epithelial ridge appeared to be the main, if not only, source of mRNA encoding Col11a1 and Col11a2 in the tectorial membrane. At postnatal Day 13, Col11a1 and Col11a2 expression became more focal and co-localized in the inner sulcus, Claudius' cells and cells of Boettcher. Conclusions - We did not observe spatial or temporal ...
Hes1 and Hes5 Activities Are Required for the Normal …
WebSep 3, 2024 · Greater epithelial ridge cells, a transient neonatal cell group in the cochlear duct, which plays a crucial role in the functional maturation of hair cell, structural development of tectorial membrane, and refinement of audio localization before hearing. WebSep 3, 2024 · Greater epithelial ridge cells, a transient neonatal cell group in the cochlear duct, which plays a crucial role in the functional maturation of hair cell, structural … shannon sharpe memes
New inner ear hair cells grow in rat tissue - Science News
WebSep 29, 2024 · We found that the greater epithelial ridge (GER), a transient cell population that disappears during postnatal cochlear maturation, harbors the most potent organoid-forming cells. GER cells grew into large organoids that, when attached to an adherent substrate, continued to expand into large colonies with many cells organized in sensory ... WebNov 10, 2024 · In the neonatal cochlea, the greater epithelial ridge (GER) is a mitotically quiescent and transient organ, which has been shown to nonmitotically regenerate SCs. Here, we ablated Lgr5 + SCs using Lgr5-DTR mice and found mitotic regeneration of SCs by GER cells in vivo. WebMar 1, 2024 · Greater epithelial ridge normally exists in the late embryonic. and early postnatal stages and is located around the inner hair. cells, which is one of the signs of immature cochlear morphology pomoly wood tent stove