Fhbb protein

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August undefined, 2024

WebAug 2, 2024 · T. denticola has several virulence factors such as dentilisin , the major surface protein , and factor H-binding protein B , which have been implicated in the progression of periodontitis. Importantly, the major surface protein of T. denticola plays a role in bacterial adherence to epithelial cells and components of the extracellular matrix [ 18 ]. WebApr 13, 2012 · FhbB is the smallest (11.4 kDa) bacterially produced FH-binding protein identified to date ( 20, 21 ). FhbB binds and positions FH on the cell surface thus …

Structure of factor H-binding protein B (FhbB) of the …

WebThe Treponema denticola FhbB Protein Is a Dominant Early Antigen That Elicits FhbB Variant-Specific Antibodies That Block Factor H Binding and Cleavage by Dentilisin. Citing article. WebFeb 24, 2012 · FhbB is a highly thermostable protein. The thermostability of FhbB was assessed by circular dichroism. CD spectrum of FhbB ( A ) and lysozyme ( C ) was measured at 4 °C prior to heating and ... fez kassel

Identification of the Gene Encoding the FhbB Protein of …

WebThe Treponema denticola FhbB protein is a dominant early antigen that elicits FhbB variant-specific antibodies that block factor H binding and cleavage by dentilisin ... Infection and Immunity 84 (7), 2051-2058, 2016. 19: 2016: A di-iron protein recruited as an Fe [II] and oxygen sensor for bacterial chemotaxis functions by stabilizing an iron ... WebThe Treponema denticola FhbB protein is a dominant early antigen that elicits FhbB variant specific antibodies that block factor H binding and cleavage by dentilisin. Infection and Immunity . PMID 27113359 DOI: 10.1128/Iai.01542-15 Webpallidum protein antigens expressed in Escherichia coli. Infect. Immun. 41:709-721. hp operating manual

Structure of Factor H-binding Protein B (FhbB) of the …

WebJan 1, 2012 · Interestingly, the size of protein recovered by the pull-down assay was ∼50 kDa (as opposed to 150 kDa for FH). Based on its size and its detection by anti-FH antiserum it was originally concluded that this protein was FHL-1 and the T. denticola binding protein was designated as FhbB (FHL-1 binding protein B (McDowell et al. … hpop 7.3 diagramWebMar 2, 2024 · The T. denticolaFH receptor has been identified as FhbB, an 11.4kDa immunodominant lipoprotein. Three distinct subfamilies of FhbB proteins have been … hp oneplus buatan mana

"WebApr 1, 2024 · Recombinant Treponema denticola Factor H binding protein B (FhbB), generated as part of an earlier study, served as control in several experiments [26]. Recombinant proteins that partitioned in the insoluble fraction (GspD and GspD sub-fragments F1 through F5) were purified using urea-denaturing conditions and then … " - Fhbb protein

Fhbb protein

WebApr 13, 2012 · FhbB possesses a unique fold that imparts high thermostability. The kinetics of the FH/FhbB interaction were assessed using surface plasmon resonance. A K (D) … WebMar 2, 2024 · Inhibition of Plg-FhbB binding by ε-aminocaproic acid (a lysine analog) indicates that binding is mediated by electrostatic interactions that presumably occur with Lys binding sites contained within Plg “Kringle” domains 1, 2, 4 or 5. ... The data presented demonstrate that FhbB is a multi-functional protein that may contribute to ...

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WebAll FhbB proteins were purified by immobilized metal affinity chromatography (HisTrap, GE Healthcare) according to the … WebThe FH binding protein of T. denticola has been identified as FhbB and its atomic structure has been determined. The interaction of FH with T. denticola is unique in that FH bound to the cell surface is cleaved by the T. denticola protease, dentilisin. It has been postulated that FH cleavage by T. denticola leads to immune dysregulation in ...

WebJun 11, 2024 · We previously demonstrated that Td binds the complement regulatory protein, factor H (FH), via the FhbB protein. FhbB is the smallest known bacterially encoded FH binding protein and its interaction with FH is unique. Full length FH is bound by FhbB at the cell surface and then FH is cleaved by the Td protease, dentilisin. A 50 kDa … WebOct 5, 2024 · Treponema denticola, a periopathogen, evades complement-mediated killing by binding the negative complement regulatory protein factor H (FH) to its surface via the FhbB protein. Paradoxically, bound ...

WebThe Treponema denticola FhbB protein is a dominant early antigen that elicits FhbB variant-specific antibodies that block Factor H binding and cleavage by Dentilisin. Infection and Immunity . 2016 Jun 23;84(7):2051-8. doi: 10.1128/IAI.01542-15. Webaipa, ompa, and asp14 in vaccine compositions and diagnostic targets for anaplasma phagocytophilum infection专利检索，aipa, ompa, and asp14 in vaccine compositions and diagnostic targets for anaplasma phagocytophilum infection属于 .来自细菌专利检索，找专利汇即可免费查询专利， .来自细菌专利汇是一家知识产权数据服务商，提供专利分 …

WebApr 17, 2024 · The factor H binding protein (FhbB) of the periodontal disease pathogen, Treponema denticola, served as a negative control antigen [45]. Statistical significance, was assessed using an unpaired, two-tailed student's t-test (95% CI, p < 0.05). All calculations were performed on GraphPad Prism 5 (GraphPad).

WebThe gene encoding the Treponema denticola factor H-like protein 1 (FHL-1) binding protein, FhbB, was recovered and characterized. Sequence conservation, expression, … fe-zke07 純正WebApr 13, 2012 · To determine the structure of the T. denticola FhbB protein (GenBank TM accession number EF032156), recombinant protein was generated.The leader peptide (residues 1–23) was replaced with a 1.7-kDa hexahistidine tag and enterokinase cleavage site. The crystallization conditions have been previously reported (). The FhbB structure … fe-zke07 楽天WebFhbB protein of the periodontal pathogen, T. denticola, and further define the molecular basis of its interaction with FH. FhbB possesses a previously undescribed protein fold … hp oneplus terbaru