Tīmeklis2024. gada 17. jūn. · The majority of BRCA1-mutant breast cancers are characterized by a triple-negative phenotype and a basal-like molecular subtype, associated with aggressive clinical behavior. Current treatment options are limited, highlighting the need for the development of novel targeted therapies for this tumor subtype. Our group … Tīmeklis2024. gada 23. nov. · Abstract. SMARCA4 and EZH2 are two functional key players of their respective antagonizing chromatin remodeling complexes SWI/SNF and PRC2. …
Chemosensitive relapse in small cell lung cancer proceeds through …
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Prevalence of Enhancer of Zeste Homolog 2 in Patients with …
Tīmeklis2024. gada 29. marts · SCLC subsets express specific surface markers, providing potential opportunities for antibody-based targeted therapies. ... Chemosensitive relapse in small cell lung cancer proceeds through an EZH2-SLFN11 axis. Cancer Cell 31, 286–299. Garnett MJ, Edelman EJ, Heidorn SJ, Greenman CD, Dastur A, Lau KW, … Tīmeklis2024. gada 1. marts · In SCLC, EZH2 mediates H3K27me3 in the enhancer region of CCL2, the low expression of which is linked to low macrophage infiltration [42]. In … TīmeklisSmall cell lung cancer (SCLC) is a subtype of lung cancer with poor prognosis. Expression array analysis of 23 SCLC cases and 42 normal tissues revealed that EZH2 and other PRC2 members were ... la housing renters rights