WebCryptophycin is a potent antitumor agent that depletes microtubules in intact cells, including cells with the multidrug resistance phenotype. To determine the mechanism of action of cryptophycin, its effects on tubulin function in vitro were analyzed. Cryptophycin reduced the in vitro polymerization of bovine brain microtubules by 50% at a drug:tubulin ratio of 0.1. WebFeb 6, 2007 · Cryptophycin 1 is a new cytotoxic antimicrotubule agent with excellent antitumor activity. The methods of Sackett (Biochemistry, 34, 7010-7019, 1995), utilizing the selective and specific ...
Antiproliferative mechanism of action of cryptophycin-52 ... - PNAS
WebTwo efficient protocols for the synthesis of tert-butyl (5S,6R,2E,7E)-5-[(tert-butyldimethylsilyl)oxy]-6-methyl-8-phenyl-2,7-octadienoate, a major component of the cryptophycins, are reported. The first utilized the Noyori reduction and Frater alkylation of methyl 5-benzyloxy-3-oxopentanoate to set two stereogenic centers, which became the … WebThe present invention provides therapeutic and diagnostic methods and compositions for cancer, for example, bladder cancer. The invention provides methods of treating bladder canc fishing trips aberdeenshire
Phase I Trial of the Cryptophycin Analogue LY355703 …
WebMar 29, 2024 · 产品名称:Cryptophycin 1. cas:124689-65-2. 描述:Cryptophycin 1 是一种从 Nostoc sp. 中分离出来的有效的细胞毒性抗微管剂。. Cryptophycin 1 可以诱导细胞凋亡,并具有抗肿瘤活性和出色的抗增殖能力。. 分子量:655.18. WebNov 1, 2006 · The unit A trifluoromethyl-modified cryptophycin proved to be highly active against KB-3-1 cells and exhibited an IC50 value in the low picomolar range, but the replacement of the 3-chloro-4-methoxyphenyl-substituent in unit B by a pentafluorophenyl moiety resulted in a significant loss of activity. Expand Web广西大学化学化工学院 教授 ,2003年11月至2005年10月,作为博士后在美国 夏威夷大学 从事抗癌活性化合物Cryptophycin新合成工艺及其 构效关系 研究。. 1991年9月至1994年12月,在 沈阳药科大学 学习,获得 药物化学专业 理学博士学位。. 1988年9月至1991年7月,在 沈 … fishing trip puerto vallarta