Camptothecin ic50
WebThe HepG2 results showed that defatted 90% MeOH and n-BuOH fractions have cytotoxic activity with IC50 ≤ 20μg/ml which falls within the American Cancer Institute criteria. ... The plant is a promising candidate for the production of camptothecin (CPT) - a high value anticancer compound. Preliminary screening of hexane and methanol extract ... WebAug 14, 2024 · Camptothecin (CPT) is a well-known anticancer drug, which causes cancer cell apoptosis via the induction of DNA damage; however, the cytotoxicity of CPT easily reaches a plateau at a relatively high dose …
Camptothecin ic50
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WebCamptothecin (CPT) is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 ?M for breast cancer cell line MDA-MB-231.; IC50 Value: 50 nM(in MDA-MB-231 cell line); Target: topoisomerase; Camptothecin (CPT) has recently been undergoing phase I clinical trials. MedChem Express HY-16560 WebOct 1, 2006 · a Camptothecin is a 5-ring heterocyclic alkaloid that contains an a-hydroxylactone within its E-ring that is unstable at physiological pH. For all camptothecin derivatives, the carboxylate...
Web9-Aminocamptothecin (9-amino-CPT) is a topoisomerase I inhibitor with potent anticancer activity. 9-Aminocamptothecin inhibits PC-3, PC-3M, DU145, and LNCaP cells with IC50 values of 34.1, 10, 6.5, and 8.9 nM, respectively after 96 h exposure. Buy Topoisomerase inhibitor 9-Aminocamptothecin (9-amino-CPT; 9-amino-20(S)-camptothecin) from … WebMay 11, 2016 · On the other hand, the same degree of sensitivity from the 2D system did not translate to a 3D culture system, resulting in higher IC50 values than the 2D system. 38 Greatly reduced cell viabilities from DXR treatments were observed from uterus/endometrium cancer (KLE) and colon carcinoma (HCT116), osteogenic sarcoma …
WebDec 8, 2003 · This enzyme is the sole target of the camptothecin family of anticancer compounds, which acts by stabilizing the covalent protein-DNA complex and enhancing apoptosis through blocking the advancement of replication forks ... Macromolecules Proteins 1 Nucleic Acids / Hybrid 2 Find similar proteins by: (by identity cutoff) 3D Structure WebThe present study aims to continue the study of corchorusoside C (1), a cardenolide isolated from Streptocaulon juventas, as a potential anticancer agent. A mechanistic study was …
WebDrug: Camptothecin - Cancerrxgene - Genomics of Drug Sensitivity in Cancer Genomics of Drug Sensitivity in Cancer Compound: Camptothecin Drug Target: TOP1 Drug Target pathway: DNA replication Dataset GDSC2 Tissue specific analysis Overview IC50 by tissue Volcano Plot Scatter Plot Compare compound IC50 AUC
WebCamptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian … orbea gain/vibe/optima range extender 208whWebIC50 0.68μM － － － － 体外研究 Camptothecin是1966年最先从Camptotheca acuminate独立的植物碱。有效且特定抑制DNA拓扑异构酶 I(topo I)，IC50为0.68μM … ipms hellas club f groupacebookWebMay 22, 2024 · FTIR and NMR spectra conformed functional moieties and structure of isolated camptothecin which was nearly equal to values mentioned in standard structure of camptothecin. IC50 values of CPT against LNCaP cell lines was found to be 3.561 μg/ml. Lambda max of CPT was found to be at 225 nm and calibration curve found to be linear … ipms hamsWebDec 1, 2024 · Camptothecin (CPT) was discovered from plant extracts more than 60 years ago. Since then, only two CPT analogues (irinotecan and topotecan) have been … orbea gain d50 2022 weightWebTo support your products in today’s complex global marketplace, you need an approach that is tailored to your unique product and distribution strategy. WuXi AppTec has supported … ipms hellasWebApr 23, 2024 · AMG-510 almost completely inhibited pERK (IC50 ≈ 0.03 μM) in NCI-H358 and MIA PaCa-2 cells after 2 h of treatment, and its IC50 value was 20 times that of ARS … ipms holdings ltdWebThe IC50 of Camptothecin in relation to these two parameters was 5.2180 μM on average. Figure 2 shows that higher Camptothecin concentrations lead to an increase in clumpy … orbea grow 2